Knock twice before invading

Knock twice before invading

Knock twice before invading eisseria meningitidis , also known as meningococcus, is a pathogen with a nasty habit of forcing normally nonphagocytic endothelial cells to engulf it, allowing the bacterium to penetrate cellular barriers. Hoffmann et al. now demonstrate on page 133 that N. meningitidis activates two distinct signaling pathways in host cells to cause actin cytoskeleton reorganizatio...

Better think before agreeing twice

Think twice before you tell

Answer to the Rhythm Puzzle At first glance the ECG looks very abnormal. The P-wave morphology is not compatible with sinus rhythm, the conduction intervals are normal, and the QRS complexes are very abnormal in amplitude (micro-voltages in the extremity leads). In lead II there is almost no signal at all. Althoughmicro-voltages in the extremity leads are a common feature in one of the most pre...

Think Twice Before Running ! Bank Runs and Cognitive Abilities

We assess the e ect of cognitive abilities on withdrawal decisions in a bank-run game. In our setup, depositors choose sequentially between withdrawing or keeping their funds deposited in a common bank. Depositors may observe previous decisions depending on the information structure. Theoretically, the last depositor in the sequence of decisions has a dominant strategy and should always keep th...

Think Twice Before You Buy! How Recommendations Affect Three-Stage Purchase Decision Processes

Consumer decision-making is usually modeled as a two-stage process of initial screening and subsequent in-depth consideration of attractive alternatives. Recent evidence indicates, however, that consideration is not necessarily the direct precursor of choice: consumers may narrow their consideration sets further to the choice set. We examine how choices in a three-stage purchase decision proces...